Biomarker Group Leader (Principal Scientist)

About the role

Roche's CICoR team in China accelerates early-phase clinical development through patient selection and enrichment and the generation and analysis of clinical biomarker data, supporting proof-of-mechanism demonstrations and faster decisions. The Biomarker Group Leader leads the biomarker team and delivers rigorous biomarker support across multiple disease areas, including Oncology, Immunology, Neurology, Cardiovascular & Metabolism and Ophthalmology, advancing translational science in China.

Key responsibilities

• Lead and mentor a multidisciplinary team of biomarker experts while remaining an individual contributor.
• Define and drive the China biomarker strategy for early- and late-phase programs, including feasibility assessments and execution plans.
• Act as biomarker subject matter expert on clinical development project teams, advising on disease biology and biomarker science.
• Support the generation and review of clinical development documents such as protocols and informed consent forms.
• Partner with global teams to run biomarker studies, including data analysis, interpretation and reporting.
• Integrate preclinical, clinical and real-world data to guide indication selection and patient enrichment strategies.
• Design and lead forward and reverse translational research studies with internal and external partners.
• Stay ahead of new biomarker modalities and technologies to harmonize biomarker platforms across the portfolio.
• Lead biomarker assay outsourcing, overseeing assay development, transfer, validation and execution at CROs, and validate CRO results for data integrity.
• Select and manage external vendors and collaborators to deliver high-quality data on time.

Required profile

• PhD or MD in a relevant scientific field (e.g. Molecular Biology, Cell Biology, Oncology, Immunology).
• At least 5 years of pharmaceutical industry experience in Translational Medicine, Clinical Development or biology research, with a strong preference for biomarker research or clinical biomarker development.
• Proven end-to-end clinical drug development experience, including drafting protocols and informed consent forms.
• Deep familiarity with the regulatory landscape and competitive environment in China.
• Excellent communication in English and Chinese, with the ability to influence stakeholders and drive consensus.

Required skills

• Extensive knowledge of biomarker technologies: immunoassays, NGS, IHC, FACS, PCR and imaging modalities (MRI, DXA, PET)
• Ability to generate and interpret data from diverse sample types to support dose selection and patient enrichment
• Strong leadership, coaching and analytical skills