Senior/Principal Clinical Pharmacologist

About the role

AstraZeneca is hiring a Senior/Principal Clinical Pharmacologist for its Shanghai Jing'An office. The role ensures the optimal use of clinical pharmacokinetics (PK), pharmacodynamics (PD) and modelling and simulation (M&S) across clinical development programs, including dose justification for the Asian population and regulatory support.

Key responsibilities

• Design and conduct clinical studies, including clinical pharmacology (CP) studies, covering dosing rationales and sampling schemes
• Analyse data (e.g. M&S) to define dose-exposure-response relationships and interpret results
• Play a central role in justifying dose recommendations for the Asian population using quantitative approaches
• Promote M&S approaches in clinical development programs wherever applicable
• Develop mathematical and statistical models to understand disease mechanisms, progression and PK/PD, and run meta-analyses where appropriate
• Prepare and defend regulatory submissions and handle regulatory interactions such as end-of-phase consultations and query responses
• Work with internal and external stakeholders on assigned projects
• Research literature, share knowledge and publish clinical pharmacology articles and reviews in peer-reviewed journals when applicable
• Train junior CP staff

Required profile

• Advanced training with a degree such as PhD, PharmD or MD; a master's degree applicant must have a strong technical background and a proven track record delivering drug development projects
• Experience in drug clinical development, including both early and late phase
• Fluent spoken and written Mandarin and English
• Ability to contribute own learning, ideas and experience to internal stakeholders
• Excellent communication, analytical and problem-solving skills